An integrated metabolomic and proteomic approach for the identification of covalent inhibitors of the main protease (Mpro) of SARS-COV-2 from crude natural extractsArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Analysis applied approach baicalein binding carried catalytic characteristic Chinese complementary complex Compound Covalent binder Cys145 database drug target electrophilic Final functional HIS163 HIS164 His41 independent inhibitor inhibitors Ion knowledge M pro M(pro) mass mass spectrometry maturation metabolomic metabolomics Michael molecular dynamics MPro nucleophilic peptide platform polyprotein protease protein-ligand Proteins proteomic proteomics residue SARS-CoV-2 SARS-CoV-2. Scutellaria baicalensis tested the SARS-CoV-2 [DOI] 10.1016/j.talanta.2022.123824 PMC 바로가기
Efficient discovery of potential inhibitors for SARS-CoV-2 3C-like protease from herbal extracts using a native MS-based affinity-selection method천연 MS 기반 친화성 선택 방법을 사용하여 허브 추출물에서 SARS-CoV-2 3C 유사 프로테아제에 대한 잠재적 억제제의 효율적인 발견Article Published on 2022-02-052022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CL 3CL Protease 3CLpro acquisition acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 applied baicalein binding affinity characterized China Cirsium Complexes Compound compounds conducted Coronaviral coronavirus COVID-19 COVID-19 therapy Data acquisition Data processing Effectiveness efficient effort flavonoids Forsythia fraction Fractions Glycyrrhiza uralensis identify incubated Infection inhibitor investigated life cycle Ligand Lonicera japonica Native Native MS natural natural product outcomes protease protein-ligand resources SARS-CoV-2 scutellarein Scutellaria baicalensis severe acute respiratory syndrome Coronavirus small molecule Standard TCM therapy Traditional Chinese medicine traditional Chinese medicine. traditional Chinese medicines Treatment UHPLC Virus life cycle were used [DOI] 10.1016/j.jpba.2021.114538 PMC 바로가기 [Article Type] Article
Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitroScutellaria baicalensis 추출물 및 Baicalein은 SARS-COV-2 및 그의 3C- 유사 프로테아제의 복제를 시험관 내에서 억제합니다.Article Published on 2021-12-012022-08-31 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] SARS, 치료제, [키워드] 3C-like protease 3CL pro analogue Anti-SARS-CoV-2 Activity baicalein baicalein. broad spectrum Compound Concentration COVID-19 drug Drug discovery drugs Ethanol global pandemic in vitro inhibit inhibit SARS-CoV-2 protease Replication replication of SARS-CoV-2 SARS-CoV SARS-CoV-2 Scutellaria baicalensis Vero Cell Vero cells Viral viral entry virus while [DOI] 10.1080/14756366.2021.1873977 PMC 바로가기 [Article Type] Article
Simple and Rapid Method for Wogonin Preparation and Its BiotransformationArticle Published on 2021-08-202022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, SARS, [키워드] Radix Scutellariae Scutellaria baicalensis activities anticancer baicalein baikal skullcap Biotransformation catalyzed Chinese complement COVID-19 determine effective exhibit glucoside glycosylation ingredient Isolation knowledge lack management Medicine metabolism microorganism microorganisms Phase I preparation provide Rapid Scutellaria baicalensis simple tested therapeutic therapeutic use was used were used wogonin [DOI] 10.3390/ijms22168973 PMC 바로가기 [Article Type] Article
He-Jie-Shen-Shi Decoction as an Adjuvant Therapy on Severe Coronavirus Disease 2019: A Retrospective Cohort and Potential Mechanistic StudyPharmacology Published on 2021-06-182022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome adjuvant Analysis ARDS Bupleurum can be used CCL2 Chinese Clinical efficacy Clinical practice combination therapy component composed conducted coronavirus disease Coronavirus disease 2019 COVID-19 Cytoscape Decoction Effect endothelial Fever GeneCard Glycyrrhiza uralensis growth factor he-jie-shen-shi decoction IL1B Inflammatory response inheritance inhibiting viral replication involved KEGG Kyoto Ligand Lung injury Man MAPK MAPK signaling MAPK3 mechanism mechanisms Medicine monotherapy Necrosis Negative conversion network network pharmacology nine notable nucleic acid oxidative stress p53 pathway Pathways Patient Pharmacology Pinellia ternata Potential PPI predict Protein Protein–protein interaction PTGS2 receptor required Result retrospective cohort study screened Scutellaria baicalensis selected severe COVID-19 shown suggested syndrome System T cell receptor target TCMSP therapeutic therapy TNF Toll-like receptor Tongji Hospital TP53 Traditional Traditional Chinese medicine treat Vascular VEGF VEGFA Wuhan [DOI] 10.3389/fphar.2021.700498 PMC 바로가기 [Article Type] Pharmacology
The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitroResearch article Published on 2021-01-012022-10-05 Journal: Biochemical pharmacology [Category] 치료법, [키워드] activities acute lung injury administration analysis of variance ANOVAanalysis of variance average steady-state plasma concentration baicalein BALFbronchoalveolar lavage fluid Body weight loss Bronchoalveolar lavage fluid Cavgaverage steady-state plasma concentration CC50half-cytotoxic concentration cell damage Cmaxpeak plasma concentration Concentration Coronavirus disease 2019 COVID-19 COVID-19coronavirus disease 2019 CPEcytopathic effect Cytopathic effect dengue virus DENVdengue virus EC50half-maximal effective concentrations EEPend-expiratory pause effective Effects end-expiratory pause enhanced pause H & EHematoxylin and eosin hACE2 hACE2human angiotensin-converting enzyme 2 half-cytotoxic concentration half-maximal effective concentrations Hematoxylin and eosin HIVhuman immunodeficiency virus Human angiotensin-converting enzyme 2 Human immunodeficiency virus IL-1β in vitro in vivo infected with SARS-CoV-2 inflammatory cell infiltration inhibit inhibited Injury Japanese encephalitis virus JEVJapanese encephalitis virus lesion LLOQLower Limit of Quantitation Lower Limit of Quantitation lung lung tissue main protease mice MOImultiplicity of infection morphology Mpromain protease multiplicity of infection peak expiratory flow peak plasma concentration PEFpeak expiratory flow Penhenhanced pause pharmacological reached Replication Respiratory function Result SARS-CoV-2 SARS-CoV-2severe acute respiratory syndrome coronavirus 2 Scutellaria baicalensis selection index serum severe acute respiratory syndrome coronavirus 2 significantly SIselection index therapeutic drug therapeutic effect TNF-α transgenic mice Treatment Vero E6 cell virus was performed Zika virus ZIKVZika virus [DOI] 10.1016/j.bcp.2020.114302 [Article Type] Research article
Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity of Scutellaria baicalensis Georgi. and its probably potential therapeutic effects on COVID-19: a reviewReview Published on 2020-09-252022-11-01 Journal: Chinese Medicine [Category] COVID-19, [키워드] absorbed activity Allergic reactions Analysis anticancer antiinflammatory Antiviral article baicalein Brain caused China Chinese Clinical symptoms clinical trials component components cough COVID-19 described disease Effects follow-up study ingredient kidney liver Liver fibrosis manifested network pharmacology pharmacokinetics pharmacological Pharmacological Effects Pharmacopoeia phytochemistry processed Research SB applications Scutellaria baicalensis shown TCM therapeutic effect therapeutic effects Toxicity treat treating COVID-19 [DOI] 10.1186/s13020-020-00384-0 PMC 바로가기 [Article Type] Review
Potential Targets for Treatment of Coronavirus Disease 2019 (COVID-19): A Review of Qing-Fei-Pai-Du-Tang and Its Major HerbsReview Published on 2020-01-012023-07-05 Journal: The American journal of Chinese medicine [Category] SARS, [키워드] Bupleurum chinense Cinnamomum cassia coronavirus Ephedra sinica Glycyrrhiza uralensis Pogostemon cablin QFPDT Scutellaria baicalensis therapeutic targets. [DOI] 10.1142/S0192415X20500512 PMC 바로가기 [Article Type] Review
Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensisArticle Published on 2015-12-242023-06-24 Journal: Journal of ethnopharmacology [Category] 신종인플루엔자, [키워드] Anti-H1N1 virus Baicalein (PubChem CID: 5281605) Baicalin (PubChem CID: 64982) chrysin (PubChem CID: 5281607) cytotoxicity Effective components Nrf2 activation oroxylin A (PubChem CID: 5320315) Scutellaria baicalensis Wogonin (PubChem CID: 5281703). [DOI] 10.1016/j.jep.2015.11.018 PMC 바로가기